Assay Detail
Binding
CHEMBL744185
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In vitro inhibition of [3H]norepinephrine uptake in rat brain synaptosomes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.67 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305905 | — | — | 1 | 7.55 |
| CHEMBL73461 | IRINDALONE | 2.0 | 1 | 7.36 |
| CHEMBL1237336 | — | — | 1 | 6.85 |
| CHEMBL70887 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305905 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL73461 | IRINDALONE | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL1237336 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL70887 | — | IC50 | = | 12000.0 | nM | 4.92 |