Assay Detail
Binding
CHEMBL744248
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Inhibition of specific binding of [3H]NMS to Muscarinic acetylcholine receptor in rat cerebral cortex by using competitive binding assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Resolved pyrrolidine, piperidine, and perhydroazepine analogues of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 6.20 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2092930 | — | — | 1 | 7.80 |
| CHEMBL1788225 | — | — | 1 | 7.38 |
| CHEMBL107456 | — | — | 1 | 7.36 |
| CHEMBL1788202 | — | — | 1 | 7.19 |
| CHEMBL432629 | — | — | 1 | 7.09 |
| CHEMBL1788224 | — | — | 1 | 6.39 |
| CHEMBL110892 | — | — | 1 | 6.17 |
| CHEMBL108140 | — | — | 1 | 6.12 |
| CHEMBL106056 | — | — | 1 | 5.91 |
| CHEMBL1788219 | — | — | 1 | 5.83 |
| CHEMBL2092931 | — | — | 1 | 5.68 |
| CHEMBL108582 | — | — | 1 | 5.65 |
| CHEMBL108557 | — | — | 1 | 5.54 |
| CHEMBL322126 | — | — | 1 | 5.29 |
| CHEMBL111327 | — | — | 1 | 5.21 |
| CHEMBL323032 | — | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2092930 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL1788225 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL107456 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL1788202 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL432629 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL1788224 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL110892 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL108140 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL106056 | — | Ki | = | 1230.0 | nM | 5.91 |
| CHEMBL1788219 | — | Ki | = | 1482.0 | nM | 5.83 |
| CHEMBL2092931 | — | Ki | = | 2070.0 | nM | 5.68 |
| CHEMBL108582 | — | Ki | = | 2260.0 | nM | 5.65 |
| CHEMBL108557 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL322126 | — | Ki | = | 5160.0 | nM | 5.29 |
| CHEMBL111327 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL323032 | — | Ki | = | 25400.0 | nM | 4.59 |