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Compound Detail

CHEMBL322126

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CC(=O)N1CCC[C@H]1C#CCN1CCCC1

Basic Information

ChEMBL ID CHEMBL322126
Phase Preclinical
Structure Type MOL
InChI Key JNDOCQKNQCJTBA-CYBMUJFWSA-N
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

220.3
MW (Da)
1.10
ALogP
2
HBA
0
HBD
23.6
PSA (Ų)
0.62
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H20N2O
MW 220.32
Aromatic Rings 0
Heavy Atoms 16
NP-Likeness -0.66

Activity Summary

Kd 1 meas. best 4.8
Ki 1 meas. best 5.29

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
Ki 5.29 5.29 5160.0 1
Muscarinic acetylcholine receptor
CHEMBL2094109
Kd 4.8 4.8 16010.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2258904 10.1021/jm00174a014 Cavia porcellus 2
2258904 10.1021/jm00174a014 Muscarinic acetylcholine receptor 1
2258904 10.1021/jm00174a014 Unchecked 1

Data from ChEMBL 36 via Core Engine