Assay Detail
Binding
CHEMBL749216
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Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileum
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL2094109) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Resolved pyrrolidine, piperidine, and perhydroazepine analogues of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 16 | 6.11 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 9.05 |
| CHEMBL2092930 | — | — | 1 | 7.10 |
| CHEMBL107456 | — | — | 1 | 7.01 |
| CHEMBL432629 | — | — | 1 | 6.96 |
| CHEMBL1788225 | — | — | 1 | 6.79 |
| CHEMBL1788202 | — | — | 1 | 6.70 |
| CHEMBL1788224 | — | — | 1 | 5.94 |
| CHEMBL110892 | — | — | 1 | 5.85 |
| CHEMBL2092932 | — | — | 1 | 5.49 |
| CHEMBL106056 | — | — | 1 | 5.45 |
| CHEMBL1788219 | — | — | 1 | 5.20 |
| CHEMBL108557 | — | — | 1 | 5.16 |
| CHEMBL2092931 | — | — | 1 | 5.11 |
| CHEMBL108582 | — | — | 1 | 5.08 |
| CHEMBL322126 | — | — | 1 | 4.80 |
| CHEMBL323032 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | Kd | = | 0.9 | nM | 9.05 |
| CHEMBL2092930 | — | Kd | = | 80.0 | nM | 7.10 |
| CHEMBL107456 | — | Kd | = | 97.0 | nM | 7.01 |
| CHEMBL432629 | — | Kd | = | 110.0 | nM | 6.96 |
| CHEMBL1788225 | — | Kd | = | 161.0 | nM | 6.79 |
| CHEMBL1788202 | — | Kd | = | 200.0 | nM | 6.70 |
| CHEMBL1788224 | — | Kd | = | 1160.0 | nM | 5.94 |
| CHEMBL110892 | — | Kd | = | 1400.0 | nM | 5.85 |
| CHEMBL2092932 | — | Kd | = | 3230.0 | nM | 5.49 |
| CHEMBL106056 | — | Kd | = | 3550.0 | nM | 5.45 |
| CHEMBL1788219 | — | Kd | = | 6320.0 | nM | 5.20 |
| CHEMBL108557 | — | Kd | = | 7000.0 | nM | 5.16 |
| CHEMBL2092931 | — | Kd | = | 7850.0 | nM | 5.11 |
| CHEMBL108582 | — | Kd | = | 8300.0 | nM | 5.08 |
| CHEMBL322126 | — | Kd | = | 16010.0 | nM | 4.80 |
| CHEMBL323032 | — | Kd | = | 125000.0 | nM | - |