Assay Detail
Binding
CHEMBL744272
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Binding affinity for rat cortex Muscarinic acetylcholine receptor M1
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M1 (CHEMBL276) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.89 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131865 | — | — | 1 | 9.30 |
| CHEMBL1202003 | — | — | 1 | 9.02 |
| CHEMBL265256 | TRIPITRAMINE | — | 1 | 8.45 |
| CHEMBL112244 | — | — | 1 | 8.36 |
| CHEMBL1202000 | — | — | 1 | 7.90 |
| CHEMBL1202001 | — | — | 1 | 7.84 |
| CHEMBL1202004 | — | — | 1 | 7.83 |
| CHEMBL1202002 | — | — | 1 | 7.60 |
| CHEMBL27673 | METHOCTRAMINE | — | 1 | 7.38 |
| CHEMBL407678 | — | — | 1 | 7.30 |
| CHEMBL134692 | — | — | 1 | 7.20 |
| CHEMBL335115 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131865 | — | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL1202003 | — | Ki | = | 0.955 | nM | 9.02 |
| CHEMBL265256 | TRIPITRAMINE | Ki | = | 3.548 | nM | 8.45 |
| CHEMBL112244 | — | Ki | = | 4.365 | nM | 8.36 |
| CHEMBL1202000 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL1202001 | — | Ki | = | 14.45 | nM | 7.84 |
| CHEMBL1202004 | — | Ki | = | 14.79 | nM | 7.83 |
| CHEMBL1202002 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL27673 | METHOCTRAMINE | Ki | = | 41.69 | nM | 7.38 |
| CHEMBL407678 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL134692 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL335115 | — | Ki | = | 316.23 | nM | 6.50 |