Assay Detail
Binding
CHEMBL744480
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M2 (CHEMBL3197) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.99 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12858 | — | — | 1 | 6.33 |
| CHEMBL13166 | — | — | 1 | 6.28 |
| CHEMBL12472 | — | — | 1 | 6.26 |
| CHEMBL268499 | — | — | 1 | 6.24 |
| CHEMBL13308 | — | — | 1 | 5.85 |
| CHEMBL275537 | — | — | 1 | 5.82 |
| CHEMBL12781 | — | — | 1 | 5.80 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 5.68 |
| CHEMBL12937 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12858 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL13166 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL12472 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL268499 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL13308 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL275537 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL12781 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL95 | TACRINE | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL12937 | — | IC50 | = | 2200.0 | nM | 5.66 |