Assay Detail
Binding
CHEMBL744481
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Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M2 (CHEMBL3197) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.27 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418712 | — | — | 1 | 6.40 |
| CHEMBL13206 | — | — | 1 | 6.30 |
| CHEMBL418714 | — | — | 1 | 6.27 |
| CHEMBL13122 | — | — | 1 | 6.23 |
| CHEMBL13426 | — | — | 1 | 6.15 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418712 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL13206 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL418714 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL13122 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL13426 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 160000.0 | nM | - |