Assay Detail
Binding
CHEMBL744482
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M2 (CHEMBL3197) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis and cholinergic properties of N-aryl-2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamino analogs of ranitidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.97 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 9.15 |
| CHEMBL7634 | OXOTREMORINE | — | 1 | 5.82 |
| CHEMBL107892 | — | — | 1 | 5.02 |
| CHEMBL321605 | — | — | 1 | 4.92 |
| CHEMBL316973 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL7634 | OXOTREMORINE | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL107892 | — | Ki | = | 9500.0 | nM | 5.02 |
| CHEMBL321605 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL316973 | — | Ki | = | 12000.0 | nM | 4.92 |