Assay Detail
Binding
CHEMBL744608
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Tested for inhibitory activity against porcine erythrocyte Mu-calpain
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Exploration of peptidyl hydrazones as water-soluble calpain inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.35 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288365 | — | — | 1 | 7.46 |
| CHEMBL40428 | — | — | 1 | 6.72 |
| CHEMBL288882 | — | — | 1 | 6.43 |
| CHEMBL40997 | — | — | 1 | 6.17 |
| CHEMBL43650 | — | — | 1 | 6.10 |
| CHEMBL39287 | — | — | 1 | 5.21 |
| CHEMBL42455 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288365 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL40428 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL288882 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL40997 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL43650 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL39287 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL42455 | — | IC50 | > | 10000.0 | nM | - |