Assay Detail
Binding
CHEMBL744927
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Inhibition of [3H]MK-801 binding to NMDA receptor of rat cerebral cortical synaptic membrane
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
(+/-)-(Z)-2-(aminomethyl)-1-phenylcyclopropanecarboxamide derivatives as a new prototype of NMDA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.80 | 5.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99946 | LEVOMILNACIPRAN | 4.0 | 1 | 5.20 |
| CHEMBL316566 | — | — | 1 | 5.00 |
| CHEMBL98994 | — | — | 1 | 4.89 |
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 4.85 |
| CHEMBL100561 | — | — | 1 | 4.06 |
| CHEMBL101447 | — | — | 1 | - |
| CHEMBL318462 | — | — | 1 | - |
| CHEMBL317169 | — | — | 1 | - |
| CHEMBL99947 | — | — | 1 | - |
| CHEMBL101715 | — | — | 1 | - |
| CHEMBL318506 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99946 | LEVOMILNACIPRAN | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL316566 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL98994 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL11 | IMIPRAMINE | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL100561 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL101447 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL318462 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL317169 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL99947 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL101715 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL318506 | — | IC50 | > | 100000.0 | nM | - |