Assay Detail
Binding
CHEMBL745029
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for NK-3 receptor was determined in vitro using isolated rat portal vein.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The dipeptide neurokinin-1 receptor antagonist S19752 is a potent and long-acting inhibitor of bronchoconstriction when administered by aerosol to the guinea pig in vivo
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.28 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305119 | — | — | 1 | 8.30 |
| CHEMBL65468 | — | — | 1 | 8.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305119 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL65468 | — | Ki | = | 5.5 | nM | 8.26 |