Assay Detail
Binding
CHEMBL745073
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Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic acetylcholine receptor M4 in NG 108-15 Cell
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | NG 108-15 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M4 (CHEMBL1821) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological activity of some 4-DAMP- related compounds
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.23 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76897 | 4-DAMP | — | 1 | 9.29 |
| CHEMBL306182 | — | — | 1 | 7.95 |
| CHEMBL9967 | PIRENZEPINE | 2.0 | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76897 | 4-DAMP | Ki | = | 0.5129 | nM | 9.29 |
| CHEMBL306182 | — | Ki | = | 11.22 | nM | 7.95 |
| CHEMBL9967 | PIRENZEPINE | Ki | = | 34.67 | nM | 7.46 |