Assay Detail
Binding
CHEMBL745132
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Inhibitory activity against MLCK (smooth muscle myosin light chain kinase)
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Myosin light chain kinase, smooth muscle (CHEMBL3062) ↗| Type | SINGLE PROTEIN |
| Organism | Gallus gallus |
Publication
Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.42 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385812 | — | — | 1 | 7.40 |
| CHEMBL443574 | — | — | 1 | 7.30 |
| CHEMBL268790 | — | — | 1 | 6.96 |
| CHEMBL425624 | — | — | 1 | 6.92 |
| CHEMBL409544 | — | — | 1 | 6.82 |
| CHEMBL267348 | — | — | 1 | 6.82 |
| CHEMBL265891 | — | — | 1 | 6.80 |
| CHEMBL262895 | — | — | 1 | 6.80 |
| CHEMBL404932 | — | — | 1 | 6.70 |
| CHEMBL216528 | — | — | 1 | 6.66 |
| CHEMBL415435 | — | — | 1 | 6.57 |
| CHEMBL262286 | — | — | 1 | 6.54 |
| CHEMBL265875 | — | — | 1 | 6.54 |
| CHEMBL264533 | — | — | 1 | 6.52 |
| CHEMBL262494 | — | — | 1 | 6.51 |
| CHEMBL386668 | — | — | 1 | 6.50 |
| CHEMBL412772 | — | — | 1 | 6.44 |
| CHEMBL264293 | — | — | 1 | 6.38 |
| CHEMBL405953 | — | — | 1 | 6.21 |
| CHEMBL1791266 | — | — | 1 | 6.14 |
| CHEMBL269727 | — | — | 1 | 6.06 |
| CHEMBL411670 | — | — | 1 | 5.98 |
| CHEMBL264267 | — | — | 1 | 5.53 |
| CHEMBL407521 | — | — | 1 | 4.70 |
| CHEMBL430273 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385812 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL443574 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL268790 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL425624 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL409544 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL267348 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL265891 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL262895 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL404932 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL216528 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL415435 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL262286 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL265875 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL264533 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL262494 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL386668 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL412772 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL264293 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL405953 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL1791266 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL269727 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL411670 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL264267 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL407521 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL430273 | — | IC50 | = | 20000.0 | nM | 4.70 |