Assay Detail
Functional
CHEMBL745193
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Antagonistic activity against muscarinic acetylcholine receptor M2
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Metabolic stabilization of benzylidene ketal M(2) muscarinic receptor antagonists via halonaphthoic acid substitution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.28 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305693 | — | — | 1 | 9.85 |
| CHEMBL309720 | — | — | 1 | 9.70 |
| CHEMBL311099 | — | — | 1 | 9.29 |
| CHEMBL74141 | — | — | 1 | 9.29 |
| CHEMBL78131 | — | — | 1 | 9.09 |
| CHEMBL308166 | — | — | 1 | 8.92 |
| CHEMBL311054 | — | — | 1 | 8.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305693 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL309720 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL311099 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL74141 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL78131 | — | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL308166 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL311054 | — | Ki | = | 1.4 | nM | 8.85 |