Assay Detail
Binding
CHEMBL745327
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Binding affinity towards NK2 receptor
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of substituted 4(Z)-(methoxyimino)pentyl-1-piperidines as dual NK1/NK2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 7.52 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144116 | — | — | 1 | 8.40 |
| CHEMBL147824 | — | — | 1 | 8.15 |
| CHEMBL342341 | — | — | 1 | 7.96 |
| CHEMBL356508 | — | — | 1 | 7.96 |
| CHEMBL343627 | — | — | 1 | 7.92 |
| CHEMBL145302 | — | — | 1 | 7.85 |
| CHEMBL145959 | — | — | 1 | 7.82 |
| CHEMBL146882 | — | — | 1 | 7.80 |
| CHEMBL126970 | — | — | 1 | 7.80 |
| CHEMBL147769 | — | — | 1 | 7.80 |
| CHEMBL144223 | — | — | 1 | 7.70 |
| CHEMBL309087 | — | — | 1 | 7.68 |
| CHEMBL343447 | — | — | 1 | 7.68 |
| CHEMBL144057 | — | — | 1 | 7.64 |
| CHEMBL356105 | — | — | 1 | 7.64 |
| CHEMBL341843 | — | — | 1 | 7.58 |
| CHEMBL122643 | — | — | 1 | 7.58 |
| CHEMBL357853 | — | — | 1 | 7.57 |
| CHEMBL144249 | — | — | 1 | 7.55 |
| CHEMBL130354 | — | — | 1 | 7.48 |
| CHEMBL144010 | — | — | 1 | 7.41 |
| CHEMBL144887 | — | — | 1 | 7.41 |
| CHEMBL148282 | — | — | 1 | 7.33 |
| CHEMBL356268 | — | — | 1 | 7.28 |
| CHEMBL144011 | — | — | 1 | 7.24 |
| CHEMBL342572 | — | — | 1 | 7.23 |
| CHEMBL147924 | — | — | 1 | 7.17 |
| CHEMBL356796 | — | — | 1 | 7.17 |
| CHEMBL145314 | — | — | 1 | 7.04 |
| CHEMBL147767 | — | — | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144116 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL147824 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL342341 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL356508 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL343627 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL145302 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL145959 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL146882 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL126970 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL147769 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL144223 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL309087 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL343447 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL144057 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL356105 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL122643 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL341843 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL357853 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL144249 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL130354 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL144010 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL144887 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL148282 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL356268 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL144011 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL342572 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL147924 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL356796 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL145314 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL147767 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL147715 | — | Ki | = | 144.0 | nM | 6.84 |
| CHEMBL146947 | — | Ki | = | 146.0 | nM | 6.84 |
| CHEMBL144668 | — | Ki | = | 195.0 | nM | 6.71 |