Assay Detail
Binding
CHEMBL745515
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Compound was evaluated for the competitive inhibition of [3H]pirenzepine binding to Muscarinic acetylcholine receptor M1 of mouse cerebral cortex
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M1 (CHEMBL3733) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.09 | 6.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268499 | — | — | 1 | 6.27 |
| CHEMBL12472 | — | — | 1 | 6.27 |
| CHEMBL12937 | — | — | 1 | 6.20 |
| CHEMBL12858 | — | — | 1 | 6.18 |
| CHEMBL12781 | — | — | 1 | 6.17 |
| CHEMBL13166 | — | — | 1 | 6.09 |
| CHEMBL275537 | — | — | 1 | 5.96 |
| CHEMBL13308 | — | — | 1 | 5.96 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268499 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL12472 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL12937 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL12858 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL12781 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL13166 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL275537 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL13308 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL95 | TACRINE | IC50 | = | 2000.0 | nM | 5.70 |