Assay Detail
Functional
CHEMBL745618
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Inhibitory concentration against electrically evoked contractions of guinea pig ileum longitudinal muscle-myenteric plexus
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Cyclic enkephalin analogs with exceptional potency at peripheral delta opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.71 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2372327 | — | — | 1 | 7.50 |
| CHEMBL2372328 | — | — | 1 | 7.44 |
| CHEMBL339320 | — | — | 1 | 7.08 |
| CHEMBL2372314 | — | — | 1 | 6.92 |
| CHEMBL2372329 | — | — | 1 | 6.68 |
| CHEMBL2372310 | — | — | 1 | 6.19 |
| CHEMBL31421 | — | — | 1 | 5.14 |
| CHEMBL317956 | DELTORPHIN C | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2372327 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2372328 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL339320 | — | IC50 | = | 82.7 | nM | 7.08 |
| CHEMBL2372314 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2372329 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2372310 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL31421 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL317956 | DELTORPHIN C | IC50 | > | 1500.0 | nM | - |