Assay Detail
Binding
CHEMBL745644
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The N4 nitrogen of pirenzepine is responsible for selective binding of the M1 subtype human muscarinic receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.33 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279453 | — | — | 1 | 8.28 |
| CHEMBL17045 | OTENZEPAD | 2.0 | 1 | 7.28 |
| CHEMBL611476 | — | — | 1 | 7.15 |
| CHEMBL9967 | PIRENZEPINE | 2.0 | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279453 | — | Ki | = | 5.28 | nM | 8.28 |
| CHEMBL17045 | OTENZEPAD | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL611476 | — | Ki | = | 71.2 | nM | 7.15 |
| CHEMBL9967 | PIRENZEPINE | Ki | = | 251.0 | nM | 6.60 |