Assay Detail
Binding
CHEMBL745670
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]pirenzepine binding at Muscarinic acetylcholine receptor M1 in rat brain P2 membranes.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M1 (CHEMBL276) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
3'-Chloro-3 alpha-(diphenylmethoxy)tropane but not 4'-chloro-3 alpha-(diphenylmethoxy)tropane produces a cocaine-like behavioral profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 9.10 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3084910 | — | — | 1 | 9.39 |
| CHEMBL3084869 | — | — | 1 | 9.37 |
| CHEMBL3084878 | — | — | 1 | 9.30 |
| CHEMBL1201203 | BENZTROPINE | 4.0 | 1 | 9.23 |
| CHEMBL3084907 | — | — | 1 | 9.22 |
| CHEMBL3084909 | — | — | 1 | 9.07 |
| CHEMBL3084870 | — | — | 1 | 9.01 |
| CHEMBL3084891 | AMINOBENZTROPINE | — | 1 | 8.95 |
| CHEMBL310310 | — | — | 1 | 8.83 |
| CHEMBL3084901 | — | — | 1 | 8.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3084910 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL3084869 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL3084878 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL1201203 | BENZTROPINE | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL3084907 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL3084909 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL3084870 | — | Ki | = | 0.98 | nM | 9.01 |
| CHEMBL3084891 | AMINOBENZTROPINE | Ki | = | 1.12 | nM | 8.95 |
| CHEMBL310310 | — | Ki | = | 1.48 | nM | 8.83 |
| CHEMBL3084901 | — | Ki | = | 2.52 | nM | 8.60 |