Assay Detail
Binding
CHEMBL745937
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibition of [3H]CPP binding from N-methyl-D-aspartate glutamate receptor in the rat cortical membranes.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
New and versatile approaches to the synthesis of CPP-related competitive NMDA antagonists. Preliminary structure-activity relationships and pharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.11 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL291278 | N-METHYL-D-ASPARTIC ACID (NMDA) | 2.0 | 1 | 5.34 |
| CHEMBL29624 | — | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL291278 | N-METHYL-D-ASPARTIC ACID (NMDA) | IC50 | = | 4550.0 | nM | 5.34 |
| CHEMBL29624 | — | IC50 | = | 13300.0 | nM | 4.88 |