Assay Detail
Binding
CHEMBL746303
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Binding affinity against human muscarine receptor (hM2) cloned in CHO cells
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and affinity studies of himbacine derived muscarinic receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.65 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277642 | HIMBACINE | — | 2 | 8.33 |
| CHEMBL301670 | — | — | 1 | 7.02 |
| CHEMBL57485 | — | — | 1 | 6.77 |
| CHEMBL294663 | — | — | 1 | 6.51 |
| CHEMBL56275 | — | — | 1 | 6.17 |
| CHEMBL58824 | — | — | 1 | 6.07 |
| CHEMBL291562 | — | — | 1 | 5.94 |
| CHEMBL430587 | — | — | 1 | 5.93 |
| CHEMBL55698 | — | — | 1 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277642 | HIMBACINE | Ki | = | 4.677 | nM | 8.33 |
| CHEMBL277642 | HIMBACINE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL301670 | — | Ki | = | 95.5 | nM | 7.02 |
| CHEMBL57485 | — | Ki | = | 169.82 | nM | 6.77 |
| CHEMBL294663 | — | Ki | = | 309.03 | nM | 6.51 |
| CHEMBL56275 | — | Ki | = | 676.08 | nM | 6.17 |
| CHEMBL58824 | — | Ki | = | 851.14 | nM | 6.07 |
| CHEMBL291562 | — | Ki | = | 1148.15 | nM | 5.94 |
| CHEMBL430587 | — | Ki | = | 1174.9 | nM | 5.93 |
| CHEMBL55698 | — | Ki | = | 1737.8 | nM | 5.76 |