Assay Detail
Binding
CHEMBL746308
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Ability to displace [3H]- pirenzepine from M1 receptor in rat hippocampal membranes
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M1 (CHEMBL276) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Acylhydrazones as M1/M3 selective muscarinic agonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 4.62 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40121 | — | — | 1 | 5.42 |
| CHEMBL312957 | — | — | 1 | 5.32 |
| CHEMBL313565 | — | — | 1 | 5.10 |
| CHEMBL81954 | — | — | 1 | 5.06 |
| CHEMBL420596 | — | — | 1 | 5.05 |
| CHEMBL84985 | — | — | 1 | 5.02 |
| CHEMBL84109 | — | — | 1 | 5.00 |
| CHEMBL85952 | — | — | 1 | 4.87 |
| CHEMBL314796 | — | — | 1 | 4.84 |
| CHEMBL82012 | — | — | 1 | 4.82 |
| CHEMBL278681 | — | — | 1 | 4.80 |
| CHEMBL314421 | — | — | 1 | 4.60 |
| CHEMBL418933 | — | — | 1 | 4.60 |
| CHEMBL83410 | — | — | 1 | 4.60 |
| CHEMBL85729 | — | — | 1 | 4.55 |
| CHEMBL85999 | — | — | 1 | 4.52 |
| CHEMBL85953 | — | — | 1 | 4.52 |
| CHEMBL84135 | — | — | 1 | 4.47 |
| CHEMBL84222 | — | — | 1 | 4.42 |
| CHEMBL432186 | — | — | 1 | 4.39 |
| CHEMBL84278 | — | — | 1 | 4.22 |
| CHEMBL83905 | — | — | 1 | 4.19 |
| CHEMBL84825 | — | — | 1 | 4.12 |
| CHEMBL421531 | — | — | 1 | 4.11 |
| CHEMBL86224 | — | — | 1 | 4.05 |
| CHEMBL83874 | — | — | 1 | 4.00 |
| CHEMBL312200 | — | — | 1 | 4.00 |
| CHEMBL315347 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40121 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL312957 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL313565 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL81954 | — | Ki | = | 8800.0 | nM | 5.06 |
| CHEMBL420596 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL84985 | — | Ki | = | 9500.0 | nM | 5.02 |
| CHEMBL84109 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL85952 | — | Ki | = | 13600.0 | nM | 4.87 |
| CHEMBL314796 | — | Ki | = | 14400.0 | nM | 4.84 |
| CHEMBL82012 | — | Ki | = | 15200.0 | nM | 4.82 |
| CHEMBL278681 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL314421 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL418933 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL83410 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL85729 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL85999 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL85953 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL84135 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL84222 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL432186 | — | Ki | = | 41000.0 | nM | 4.39 |
| CHEMBL84278 | — | Ki | = | 60000.0 | nM | 4.22 |
| CHEMBL83905 | — | Ki | = | 65000.0 | nM | 4.19 |
| CHEMBL84825 | — | Ki | = | 76000.0 | nM | 4.12 |
| CHEMBL421531 | — | Ki | = | 78000.0 | nM | 4.11 |
| CHEMBL86224 | — | Ki | = | 90000.0 | nM | 4.05 |
| CHEMBL83874 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL312200 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL315347 | — | Ki | = | 180000.0 | nM | - |