Assay Detail
Binding
CHEMBL746355
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Binding activity against Muscarinic acetylcholine receptor in rat cortex, using [3H]QNB as a radioligand.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Chemical and biochemical studies of 2-propynylpyrrolidine derivatives. Restricted-rotation analogues of N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide (BM-5).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 4.94 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110208 | — | — | 1 | 5.34 |
| CHEMBL1203011 | — | — | 1 | 5.30 |
| CHEMBL1203013 | — | — | 1 | 5.07 |
| CHEMBL321684 | — | — | 1 | 4.68 |
| CHEMBL108411 | — | — | 1 | 4.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110208 | — | Ki | = | 4590.0 | nM | 5.34 |
| CHEMBL1203011 | — | Ki | = | 4960.0 | nM | 5.30 |
| CHEMBL1203013 | — | Ki | = | 8500.0 | nM | 5.07 |
| CHEMBL321684 | — | Ki | = | 20900.0 | nM | 4.68 |
| CHEMBL108411 | — | Ki | = | 48900.0 | nM | 4.31 |