Assay Detail
Binding
CHEMBL746417
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Inhibition of [3H]pirenzepine binding to mouse muscarinic acetylcholine receptor M1 from cerebral cortex
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M1 (CHEMBL3733) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis and cholinergic properties of N-aryl-2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamino analogs of ranitidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.74 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107673 | — | — | 1 | 6.42 |
| CHEMBL320291 | — | — | 1 | 6.37 |
| CHEMBL318517 | — | — | 1 | 6.28 |
| CHEMBL106348 | — | — | 1 | 6.17 |
| CHEMBL106344 | — | — | 1 | 5.82 |
| CHEMBL104681 | — | — | 1 | 5.75 |
| CHEMBL106936 | — | — | 1 | 5.70 |
| CHEMBL107254 | — | — | 1 | 5.68 |
| CHEMBL106932 | — | — | 1 | 5.51 |
| CHEMBL106782 | — | — | 1 | 5.50 |
| CHEMBL106082 | — | — | 1 | 5.48 |
| CHEMBL107892 | — | — | 1 | 5.42 |
| CHEMBL321605 | — | — | 1 | 5.42 |
| CHEMBL104355 | — | — | 1 | 5.40 |
| CHEMBL108163 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107673 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL320291 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL318517 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL106348 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL106344 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL104681 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL106936 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL107254 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL106932 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL106782 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL106082 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL107892 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL321605 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL104355 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL108163 | — | IC50 | = | 6400.0 | nM | 5.19 |