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Assay Detail

CHEMBL746554

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [3H]CPP binding to N-methyl-D-aspartate glutamate receptor of rat cortical or hippocampal membranes
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Subcellular Membrane
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Glutamate NMDA receptor (CHEMBL1907608)
Type PROTEIN COMPLEX GROUP
Organism Rattus norvegicus

Publication

2,4-Dihydro-3H-1,2,4-triazol-3-ones as anticonvulsant agents.
Kane JM, Baron BM, Dudley MW, Sorensen SM, Staeger MA, Miller FP.
J Med Chem (1990) 33 : 2772 -2777
PubMed 2170646 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.22 5.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL291278 N-METHYL-D-ASPARTIC ACID (NMDA) 2.0 1 5.22
CHEMBL96550 1 -
CHEMBL96819 1 -
CHEMBL96664 1 -
CHEMBL96556 1 -
CHEMBL92675 1 -
CHEMBL93188 1 -
CHEMBL91919 1 -
CHEMBL96557 1 -
CHEMBL94806 1 -
CHEMBL94808 1 -
CHEMBL94841 1 -
CHEMBL316452 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL291278 N-METHYL-D-ASPARTIC ACID (NMDA) IC50 = 6000.0 nM 5.22
CHEMBL96550 IC50 > 100000.0 nM -
CHEMBL96819 IC50 > 100000.0 nM -
CHEMBL96664 IC50 > 100000.0 nM -
CHEMBL96556 IC50 > 100000.0 nM -
CHEMBL92675 IC50 > 100000.0 nM -
CHEMBL93188 IC50 > 100000.0 nM -
CHEMBL91919 IC50 > 100000.0 nM -
CHEMBL96557 IC50 > 100000.0 nM -
CHEMBL94806 IC50 > 100000.0 nM -
CHEMBL94808 IC50 > 100000.0 nM -
CHEMBL94841 IC50 > 100000.0 nM -
CHEMBL316452 IC50 > 100000.0 nM -