Assay Detail
Binding
CHEMBL746556
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Displacement of [3H]CGS-19,755 from glutamate recognition site of N-methyl-D-aspartate glutamate receptor complex
11
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
6-substituted decahydroisoquinoline-3-carboxylic acids as potent and selective conformationally constrained NMDA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.29 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116889 | — | — | 2 | 6.09 |
| CHEMBL3348568 | — | — | 1 | 5.61 |
| CHEMBL280850 | — | — | 1 | 4.86 |
| CHEMBL118327 | — | — | 1 | 4.58 |
| CHEMBL325882 | — | — | 1 | - |
| CHEMBL303126 | — | — | 2 | - |
| CHEMBL420355 | — | — | 1 | - |
| CHEMBL65631 | — | — | 1 | - |
| CHEMBL118537 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116889 | — | IC50 | = | 815.0 | nM | 6.09 |
| CHEMBL3348568 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL116889 | — | IC50 | = | 4870.0 | nM | 5.31 |
| CHEMBL280850 | — | IC50 | = | 13810.0 | nM | 4.86 |
| CHEMBL118327 | — | IC50 | = | 26400.0 | nM | 4.58 |
| CHEMBL325882 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL303126 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL420355 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL65631 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL303126 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL118537 | — | IC50 | > | 10000.0 | nM | - |