Assay Detail
Binding
CHEMBL746581
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity towards Muscarinic acetylcholine receptor M1 using [3H]QNB as radioligand from rat heart tissue
5
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M1 (CHEMBL276) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Resolution and in vitro and initial in vivo evaluation of isomers of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate: a high-affinity ligand for the muscarinic receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 9.32 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2111842 | — | — | 2 | 9.89 |
| CHEMBL558910 | — | — | 1 | 9.49 |
| CHEMBL127587 | — | — | 2 | 9.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2111842 | — | Kd | = | 0.13 | nM | 9.89 |
| CHEMBL2111842 | — | Kd | = | 0.23 | nM | 9.64 |
| CHEMBL558910 | — | Kd | = | 0.32 | nM | 9.49 |
| CHEMBL127587 | — | Kd | = | 0.383 | nM | 9.42 |
| CHEMBL127587 | — | Kd | = | 6.83 | nM | 8.17 |