Assay Detail
Binding
CHEMBL746583
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Binding activity against rat muscarinic acetylcholine receptor M1 using [3H]QNB as the radioligand
17
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M1 (CHEMBL276) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis, molecular modeling studies, and muscarinic receptor activity of azaprophen analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.56 | 10.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL320611 | — | — | 2 | 10.06 |
| CHEMBL318812 | — | — | 1 | 9.66 |
| CHEMBL326640 | — | — | 1 | 8.91 |
| CHEMBL110339 | — | — | 1 | 8.53 |
| CHEMBL110808 | — | — | 1 | 8.32 |
| CHEMBL322582 | — | — | 1 | 7.96 |
| CHEMBL326453 | — | — | 1 | 5.56 |
| CHEMBL325322 | — | — | 3 | 5.15 |
| CHEMBL111529 | — | — | 3 | 5.14 |
| CHEMBL2113669 | — | — | 2 | 5.04 |
| CHEMBL607175 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320611 | — | Ki | = | 0.0881 | nM | 10.06 |
| CHEMBL318812 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL326640 | — | Ki | = | 1.23 | nM | 8.91 |
| CHEMBL110339 | — | Ki | = | 2.94 | nM | 8.53 |
| CHEMBL110808 | — | Ki | = | 4.75 | nM | 8.32 |
| CHEMBL320611 | — | Ki | = | 7.89 | nM | 8.10 |
| CHEMBL322582 | — | Ki | = | 10.9 | nM | 7.96 |
| CHEMBL326453 | — | Ki | = | 2770.0 | nM | 5.56 |
| CHEMBL325322 | — | Ki | = | 7110.0 | nM | 5.15 |
| CHEMBL111529 | — | Ki | = | 7210.0 | nM | 5.14 |
| CHEMBL325322 | — | Ki | = | 8620.0 | nM | 5.06 |
| CHEMBL2113669 | — | Ki | = | 9180.0 | nM | 5.04 |
| CHEMBL111529 | — | Ki | = | 9200.0 | nM | 5.04 |
| CHEMBL607175 | — | Ki | = | 12800.0 | nM | 4.89 |
| CHEMBL111529 | — | Ki | = | 13900.0 | nM | 4.86 |
| CHEMBL325322 | — | Ki | = | 22100.0 | nM | 4.66 |
| CHEMBL2113669 | — | Ki | = | 23100.0 | nM | 4.64 |