Assay Detail
Binding
CHEMBL746585
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Affinity versus [3H]oxotremorine M (agonist) binding to Muscarinic acetylcholine receptor M1 in Rat Cerebral Cortical Membranes, (Kd=0.75 nM)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M1 (CHEMBL276) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.71 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64000 | — | — | 1 | 8.25 |
| CHEMBL12587 | MUSCARINE | — | 1 | 7.57 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 7.51 |
| CHEMBL64788 | — | — | 1 | 6.58 |
| CHEMBL294273 | — | — | 1 | 5.58 |
| CHEMBL2115494 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64000 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL12587 | MUSCARINE | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL14 | CARBACHOL | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL64788 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL294273 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL2115494 | — | Ki | = | 18000.0 | nM | 4.75 |