Assay Detail
Binding
CHEMBL746874
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against N-methyl-D-aspartate glutamate receptor using [3H]25-6981 as radioligand.
29
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 6.80 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50872 | — | — | 1 | 8.46 |
| CHEMBL430457 | — | — | 1 | 8.00 |
| CHEMBL89765 | — | — | 1 | 8.00 |
| CHEMBL89134 | — | — | 2 | 7.96 |
| CHEMBL88330 | — | — | 1 | 7.82 |
| CHEMBL327615 | — | — | 1 | 7.77 |
| CHEMBL89173 | — | — | 1 | 7.72 |
| CHEMBL327643 | — | — | 1 | 7.66 |
| CHEMBL90216 | — | — | 1 | 7.64 |
| CHEMBL90161 | — | — | 1 | 7.58 |
| CHEMBL84677 | — | — | 1 | 7.12 |
| CHEMBL89098 | — | — | 1 | 7.00 |
| CHEMBL90046 | — | — | 1 | 6.96 |
| CHEMBL421728 | — | — | 1 | 6.58 |
| CHEMBL88556 | — | — | 1 | 6.58 |
| CHEMBL50608 | — | — | 1 | 6.38 |
| CHEMBL89068 | — | — | 1 | 6.35 |
| CHEMBL329112 | — | — | 1 | 6.30 |
| CHEMBL327412 | — | — | 1 | 5.72 |
| CHEMBL446677 | — | — | 1 | 5.43 |
| CHEMBL421166 | — | — | 1 | 5.31 |
| CHEMBL85349 | — | — | 1 | 5.12 |
| CHEMBL89617 | — | — | 1 | 5.10 |
| CHEMBL313723 | — | — | 1 | 4.48 |
| CHEMBL328364 | — | — | 1 | - |
| CHEMBL89786 | 2-PHENYLQUINOLINE | — | 1 | - |
| CHEMBL86510 | — | — | 1 | - |
| CHEMBL89353 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50872 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL430457 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL89765 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL89134 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL88330 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL327615 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL89173 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL327643 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL90216 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL90161 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL84677 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL89134 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL89098 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL90046 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL88556 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL421728 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL50608 | — | Ki | = | 413.0 | nM | 6.38 |
| CHEMBL89068 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL329112 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL327412 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL446677 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL421166 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL85349 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL89617 | — | Ki | = | 7900.0 | nM | 5.10 |
| CHEMBL313723 | — | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL89786 | 2-PHENYLQUINOLINE | Ki | > | 35000.0 | nM | - |
| CHEMBL86510 | — | Ki | > | 40000.0 | nM | - |
| CHEMBL328364 | — | Ki | > | 35000.0 | nM | - |
| CHEMBL89353 | — | Ki | > | 4000.0 | nM | - |