Assay Detail
Functional
CHEMBL746895
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In vitro concentration required to inhibit NHE-1 mediated intracellular maximal pH recovery by 50%
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.53 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355862 | ZONIPORIDE | 2.0 | 1 | 7.23 |
| CHEMBL64360 | ENIPORIDE | 2.0 | 1 | 6.85 |
| CHEMBL354137 | — | — | 1 | 6.80 |
| CHEMBL355071 | — | — | 1 | 6.46 |
| CHEMBL436559 | CARIPORIDE | 2.0 | 1 | 6.25 |
| CHEMBL352933 | — | — | 1 | 6.08 |
| CHEMBL167495 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355862 | ZONIPORIDE | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL64360 | ENIPORIDE | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL354137 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL355071 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL436559 | CARIPORIDE | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL352933 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL167495 | — | IC50 | = | 860.0 | nM | 6.07 |