Assay Detail
Binding
CHEMBL746900
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The binding affinity at the Norepinephrine transporter reuptake sites determined using competition binding assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.29 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 7.66 |
| CHEMBL654 | MIRTAZAPINE | 4.0 | 1 | 6.58 |
| CHEMBL111184 | — | — | 1 | 5.91 |
| CHEMBL324270 | — | — | 1 | 5.75 |
| CHEMBL113238 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6437 | MIANSERIN | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL654 | MIRTAZAPINE | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL111184 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL324270 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL113238 | — | IC50 | = | 2860.0 | nM | 5.54 |