Assay Detail
Binding
CHEMBL746905
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for Norepinephrine transporter is assessed from the ability to displace [3H]nisoxetine from rat frontal cortex
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2-substituted 3beta-tolyltropane derivatives at dopamine, serotonin, and norepinephrine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.09 | 6.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112763 | — | — | 1 | 6.67 |
| CHEMBL19944 | — | — | 1 | 6.57 |
| CHEMBL2079577 | — | — | 1 | 6.33 |
| CHEMBL2112762 | — | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112763 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL19944 | — | Ki | = | 271.0 | nM | 6.57 |
| CHEMBL2079577 | — | Ki | = | 464.0 | nM | 6.33 |
| CHEMBL2112762 | — | Ki | = | 16800.0 | nM | 4.78 |