Assay Detail
Binding
CHEMBL747069
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Concentration required for 50% Inhibition of responses at cloned NR1A/2A NMDA expressed in Xenopus oocytes
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Oocyte |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Glutamate receptor ionotropic, NMDA 1 (CHEMBL2015) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.30 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116223 | — | — | 1 | 4.60 |
| CHEMBL117260 | — | — | 1 | 4.46 |
| CHEMBL19506 | — | — | 1 | 4.42 |
| CHEMBL113697 | — | — | 1 | 4.41 |
| CHEMBL117940 | — | — | 1 | 4.41 |
| CHEMBL114823 | — | — | 1 | 4.28 |
| CHEMBL113936 | — | — | 1 | 4.24 |
| CHEMBL115883 | — | — | 1 | 4.12 |
| CHEMBL114155 | — | — | 1 | 4.05 |
| CHEMBL324584 | — | — | 1 | 4.02 |
| CHEMBL326568 | — | — | 1 | - |
| CHEMBL115761 | — | — | 1 | - |
| CHEMBL116224 | — | — | 1 | - |
| CHEMBL113750 | — | — | 1 | - |
| CHEMBL326742 | — | — | 1 | - |
| CHEMBL324940 | — | — | 1 | - |
| CHEMBL19636 | — | — | 1 | - |
| CHEMBL114644 | — | — | 1 | - |
| CHEMBL114536 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116223 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL117260 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL19506 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL113697 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL117940 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL114823 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL113936 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL115883 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL114155 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL324584 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL326568 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL115761 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL116224 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL113750 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL326742 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL324940 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL19636 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL114644 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL114536 | — | IC50 | > | 100000.0 | nM | - |