Glutamate receptor ionotropic, NMDA 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q05586. Use UniProt Q05586 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q05586 as the stable identity anchor, then attach disease evidence before program review.
Glutamate receptor ionotropic, NMDA 1
Review this target as Glutamate receptor ionotropic, NMDA 1, mapped to UniProt Q05586. Sequence length is 938 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Glutamate receptor ionotropic, NMDA 1 as ChEMBL target CHEMBL2015, mapped to UniProt Q05586. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Glutamate receptor ionotropic, NMDA 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q05586 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Glutamate receptor ionotropic, NMDA 1 |
| UniProt Accession | Q05586 |
| Component Type | Protein |
| Sequence Length | 938 aa |
Glutamate receptor ionotropic, NMDA 1
Review this target as Glutamate receptor ionotropic, NMDA 1, mapped to UniProt Q05586. Sequence length is 938 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL248247 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL246004 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL401848 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL429296 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL86313 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL117260 | 8.28 | IC50 | 5.3 | Preclinical |
| CHEMBL167952 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL19636 | 8.21 | IC50 | 6.1 | Preclinical |
| CHEMBL354295 | 8.1 | IC50 | 8.0 | Preclinical |
| CHEMBL399275 | 8.1 | IC50 | 8.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 9 | 21 | 6.9 |
| cell-based format | 7 | 25 | 6.1 |
| assay format | 2 | 23 | 6.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 23 | 7.5 |