Compound Detail
CHEMBL354295
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Basic Information
| ChEMBL ID | CHEMBL354295 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OQCIHSFMLURANM-YFKPBYRVSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
425.1
MW (Da)
1.26
ALogP
6
HBA
5
HBD
135.8
PSA (Ų)
0.37
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 CHEMBL2015 | IC50 | 8.1 | 8.1 | 8.0 | 1 |
| Glutamate receptor ionotropic AMPA CHEMBL2096670 | IC50 | 6.47 | 6.47 | 340.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 | IC50 | = | 8.0 | nM | 8.1 | Compound was evaluated for its binding affinity for the glycine binding site on ... | 10636248 |
| Glutamate receptor ionotropic AMPA | IC50 | = | 340.0 | nM | 6.47 | Compound has been evaluated for its binding affinity towards Ionotropic glutamat... | 10636248 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10636248 | 10.1016/s0960-894x(99)00576-4 | Mus musculus | 35 |
| 10636248 | 10.1016/s0960-894x(99)00576-4 | No relevant target | 7 |
| 10636248 | 10.1016/s0960-894x(99)00576-4 | Glutamate [NMDA] receptor | 2 |
| 10636248 | 10.1016/s0960-894x(99)00576-4 | Glutamate receptor ionotropic, NMDA 1 | 1 |
| 10636248 | 10.1016/s0960-894x(99)00576-4 | Glutamate receptor ionotropic AMPA | 1 |
| 10636248 | 10.1016/s0960-894x(99)00576-4 | Glutamate receptor ionotropic kainate | 1 |
Data from ChEMBL 36 via Core Engine