Assay Detail
Binding
CHEMBL880848
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its binding affinity for the glycine binding site on N-methyl-D-aspartate glutamate receptor by using [3H]MDL-105519 binding assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 1 (CHEMBL2015) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, radiolabelling and biological characterization of (D)-7-iodo-N-(1-phosphonoethyl)-5-aminomethylquinoxaline-2,3-dione, a glycine-binding site antagonist of NMDA receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.91 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86313 | — | — | 1 | 8.30 |
| CHEMBL167952 | — | — | 1 | 8.22 |
| CHEMBL82963 | — | — | 1 | 8.10 |
| CHEMBL354295 | — | — | 1 | 8.10 |
| CHEMBL162675 | — | — | 1 | 8.05 |
| CHEMBL82626 | — | — | 1 | 7.50 |
| CHEMBL164231 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86313 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL167952 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL82963 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL354295 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL162675 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL82626 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL164231 | — | IC50 | = | 76.0 | nM | 7.12 |