Compound Detail
CHEMBL401848
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL401848 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YUHHWFRRCMUUPA-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
4
Publications
0
Known Names
Molecular Properties
382.2
MW (Da)
0.37
ALogP
5
HBA
3
HBD
140.4
PSA (Ų)
0.65
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 CHEMBL2015 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 393.0 | ng.hr.mL-1 | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 | IC50 | = | 2.0 | nM | 8.7 | Antagonist activity at human NMDA NR1 receptor | 17562362 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17562362 | 10.1016/j.bmcl.2007.05.083 | Rattus norvegicus | 2 |
| 17562362 | 10.1016/j.bmcl.2007.05.083 | Liver microsomes | 2 |
| 17562362 | 10.1016/j.bmcl.2007.05.083 | Glutamate receptor ionotropic, NMDA 1 | 1 |
| 17562362 | 10.1016/j.bmcl.2007.05.083 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine