Assay Detail
Binding
CHEMBL747096
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Tested for the binding affinity towards Norepinephrine transporter in rat cerebral cortex by displacing [3H]nisoxetine radioligand
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and transporter binding properties of 3beta-[4'-(phenylalkyl, -phenylalkenyl, and -phenylalkynyl)phenyl]tropane-2beta-carboxylic acid methyl esters: evidence of a remote phenyl binding domain on the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 6.46 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2310877 | — | — | 1 | 8.19 |
| CHEMBL2310867 | — | — | 1 | 7.90 |
| CHEMBL2310871 | — | — | 1 | 7.78 |
| CHEMBL2373962 | — | — | 1 | 7.44 |
| CHEMBL2310874 | — | — | 1 | 7.37 |
| CHEMBL2310868 | — | — | 1 | 7.33 |
| CHEMBL3350431 | — | — | 1 | 7.30 |
| CHEMBL1790051 | — | — | 1 | 7.26 |
| CHEMBL2310872 | — | — | 1 | 6.68 |
| CHEMBL84680 | — | — | 1 | 6.65 |
| CHEMBL2310869 | — | — | 1 | 6.31 |
| CHEMBL2310880 | — | — | 1 | 6.22 |
| CHEMBL2310881 | — | — | 1 | 6.12 |
| CHEMBL2310873 | — | — | 1 | 6.05 |
| CHEMBL2310876 | — | — | 1 | 6.05 |
| CHEMBL2310884 | — | — | 1 | 6.02 |
| CHEMBL2310883 | — | — | 1 | 5.93 |
| CHEMBL2310865 | — | — | 1 | 5.86 |
| CHEMBL50157 | — | — | 1 | 5.63 |
| CHEMBL2310866 | — | — | 1 | 5.63 |
| CHEMBL2310875 | — | — | 1 | 5.57 |
| CHEMBL2310879 | — | — | 1 | 5.37 |
| CHEMBL2310870 | — | — | 1 | 5.24 |
| CHEMBL2310878 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2310877 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL2310867 | — | Ki | = | 12.7 | nM | 7.90 |
| CHEMBL2310871 | — | Ki | = | 16.5 | nM | 7.78 |
| CHEMBL2373962 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL2310874 | — | Ki | = | 42.3 | nM | 7.37 |
| CHEMBL2310868 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL3350431 | — | Ki | = | 50.1 | nM | 7.30 |
| CHEMBL1790051 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL2310872 | — | Ki | = | 209.0 | nM | 6.68 |
| CHEMBL84680 | — | Ki | = | 224.0 | nM | 6.65 |
| CHEMBL2310869 | — | Ki | = | 494.0 | nM | 6.31 |
| CHEMBL2310880 | — | Ki | = | 606.0 | nM | 6.22 |
| CHEMBL2310881 | — | Ki | = | 759.0 | nM | 6.12 |
| CHEMBL2310873 | — | Ki | = | 885.0 | nM | 6.05 |
| CHEMBL2310876 | — | Ki | = | 892.0 | nM | 6.05 |
| CHEMBL2310884 | — | Ki | = | 958.0 | nM | 6.02 |
| CHEMBL2310883 | — | Ki | = | 1180.0 | nM | 5.93 |
| CHEMBL2310865 | — | Ki | = | 1390.0 | nM | 5.86 |
| CHEMBL50157 | — | Ki | = | 2360.0 | nM | 5.63 |
| CHEMBL2310866 | — | Ki | = | 2360.0 | nM | 5.63 |
| CHEMBL2310875 | — | Ki | = | 2680.0 | nM | 5.57 |
| CHEMBL2310879 | — | Ki | = | 4260.0 | nM | 5.37 |
| CHEMBL2310870 | — | Ki | = | 5720.0 | nM | 5.24 |
| CHEMBL2310878 | — | Ki | = | 8500.0 | nM | 5.07 |