Assay Detail
Functional
CHEMBL747117
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic potency against Muscarinic acetylcholine receptor M2
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 6.94 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27673 | METHOCTRAMINE | — | 1 | 7.92 |
| CHEMBL422977 | — | — | 1 | 7.64 |
| CHEMBL302179 | — | — | 1 | 6.98 |
| CHEMBL132377 | — | — | 1 | 6.67 |
| CHEMBL134382 | — | — | 1 | 6.67 |
| CHEMBL11805 | CAPROCTAMINE | — | 1 | 6.39 |
| CHEMBL134488 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27673 | METHOCTRAMINE | Kd | = | 12.02 | nM | 7.92 |
| CHEMBL422977 | — | Kd | = | 22.91 | nM | 7.64 |
| CHEMBL302179 | — | Kd | = | 104.71 | nM | 6.98 |
| CHEMBL132377 | — | Kd | = | 213.8 | nM | 6.67 |
| CHEMBL134382 | — | Kd | = | 213.8 | nM | 6.67 |
| CHEMBL11805 | CAPROCTAMINE | Kd | = | 407.38 | nM | 6.39 |
| CHEMBL134488 | — | Kd | = | 501.19 | nM | 6.30 |