Assay Detail
Functional
CHEMBL747122
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Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Binary antidotes for organophosphate poisoning: aprophen analogues that are both antimuscarinics and carbamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 7.20 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL36583 | — | — | 1 | 7.30 |
| CHEMBL416974 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL36583 | — | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL416974 | — | Kd | = | 79.43 | nM | 7.10 |