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Assay Detail

CHEMBL747203

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity at glycine co-agonist site of rat NMDA receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Glutamate receptor ionotropic, NMDA 1 (CHEMBL330)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Synthesis and glutamate antagonist activity of 4-phosphonoalkylquinoline derivatives: A novel class of non-NMDA antagonist
Hamilton G, Bednar D, Borosky S, Huang Z, Zubrowski R, Ferkany J, Karbon E
Bioorg Med Chem Lett (1994) 4 : 2035 -2040
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.49 5.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL9790 1 5.10
CHEMBL294796 1 5.00
CHEMBL61550 1 4.54
CHEMBL64819 1 4.43
CHEMBL63386 1 4.16
CHEMBL64417 1 4.10
CHEMBL284012 1 4.09
CHEMBL62849 1 -
CHEMBL432901 1 -
CHEMBL305312 1 -
CHEMBL62372 1 -
CHEMBL292600 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL9790 IC50 = 7900.0 nM 5.10
CHEMBL294796 IC50 = 10000.0 nM 5.00
CHEMBL61550 IC50 = 29000.0 nM 4.54
CHEMBL64819 IC50 = 37000.0 nM 4.43
CHEMBL63386 IC50 = 69000.0 nM 4.16
CHEMBL64417 IC50 = 79000.0 nM 4.10
CHEMBL284012 IC50 = 81000.0 nM 4.09
CHEMBL62849 IC50 > 1000000.0 nM -
CHEMBL432901 IC50 = 231000.0 nM -
CHEMBL305312 IC50 > 1000000.0 nM -
CHEMBL62372 IC50 > 1000000.0 nM -
CHEMBL292600 IC50 > 1000000.0 nM -