Assay Detail
Binding
CHEMBL747235
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Tested for binding affinity against mu opioid receptor using [3H]DAMGO as a radioligand in the guinea pig brain membranes.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Electrophilic N-benzylnaltrindoles as delta opioid receptor-selective antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.09 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282518 | — | — | 1 | 7.82 |
| CHEMBL280649 | — | — | 1 | 7.18 |
| CHEMBL26648 | — | — | 1 | 6.82 |
| CHEMBL282107 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282518 | — | Ki | = | 15.3 | nM | 7.82 |
| CHEMBL280649 | — | Ki | = | 66.2 | nM | 7.18 |
| CHEMBL26648 | — | Ki | = | 151.0 | nM | 6.82 |
| CHEMBL282107 | — | Ki | = | 289.0 | nM | 6.54 |