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Assay Detail

CHEMBL747286

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against human N-Myristoyltransferase (HsNmt) assessed as inhibitory concentration using substrate peptide and myristotyl-CoA at 0.5 uM
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Peptide N-myristoyltransferase (CHEMBL2096973)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2.
Ebiike H, Masubuchi M, Liu P, Kawasaki K, Morikami K, Sogabe S, Hayase M, Fujii T, Sakata K, Shindoh H, Shiratori Y, Aoki Y, Ohtsuka T, Shimma N.
Bioorg Med Chem Lett (2002) 12 : 607 -610
PubMed 11844682 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 4.43 4.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL345610 1 4.92
CHEMBL351774 1 4.72
CHEMBL155301 1 4.21
CHEMBL158172 1 4.17
CHEMBL346363 1 4.11
CHEMBL158185 1 -
CHEMBL155240 1 -
CHEMBL347895 1 -
CHEMBL155469 1 -
CHEMBL434276 1 -
CHEMBL301315 1 -
CHEMBL154079 1 -
CHEMBL433886 1 -
CHEMBL345893 1 -
CHEMBL347048 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL345610 IC50 = 12000.0 nM 4.92
CHEMBL351774 IC50 = 19000.0 nM 4.72
CHEMBL155301 IC50 = 62000.0 nM 4.21
CHEMBL158172 IC50 = 67000.0 nM 4.17
CHEMBL346363 IC50 = 77000.0 nM 4.11
CHEMBL158185 IC50 > 400000.0 nM -
CHEMBL155240 IC50 > 480000.0 nM -
CHEMBL347895 IC50 > 470000.0 nM -
CHEMBL155469 IC50 > 460000.0 nM -
CHEMBL434276 IC50 > 470000.0 nM -
CHEMBL301315 IC50 > 450000.0 nM -
CHEMBL154079 IC50 > 110000.0 nM -
CHEMBL433886 IC50 > 110000.0 nM -
CHEMBL345893 IC50 > 450000.0 nM -
CHEMBL347048 IC50 > 430000.0 nM -