Assay Detail
Binding
CHEMBL747347
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace strychnine-insensitive [3H]glycine binding to N-methyl-D-aspartate glutamate receptor of rat cortical membranes.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
3-Phenyl-4-hydroxyquinolin-2(1H)-ones: potent and selective antagonists at the strychnine-insensitive glycine site on the N-methyl-D-aspartate receptor complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.43 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114610 | — | — | 1 | 7.89 |
| CHEMBL104298 | — | — | 1 | 7.24 |
| CHEMBL324546 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114610 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL104298 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL324546 | — | Ki | = | 67.0 | nM | 7.17 |