Assay Detail
Binding
CHEMBL747358
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cells
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor; GRIN1/GRIN2B (CHEMBL1907603) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Novel N1-(benzyl)cinnamamidine derived NR2B subtype-selective NMDA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 7.95 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423244 | — | — | 1 | 9.30 |
| CHEMBL159675 | — | — | 1 | 9.22 |
| CHEMBL158737 | — | — | 1 | 9.15 |
| CHEMBL159762 | — | — | 1 | 9.10 |
| CHEMBL159761 | — | — | 1 | 9.00 |
| CHEMBL159416 | — | — | 1 | 8.89 |
| CHEMBL159902 | — | — | 1 | 8.85 |
| CHEMBL159453 | — | — | 1 | 8.85 |
| CHEMBL159790 | — | — | 1 | 8.80 |
| CHEMBL160027 | — | — | 1 | 8.77 |
| CHEMBL161859 | — | — | 1 | 8.72 |
| CHEMBL159425 | — | — | 1 | 8.57 |
| CHEMBL350614 | — | — | 1 | 8.44 |
| CHEMBL348727 | — | — | 1 | 8.24 |
| CHEMBL159306 | — | — | 1 | 8.14 |
| CHEMBL158874 | — | — | 1 | 8.05 |
| CHEMBL305195 | — | — | 1 | 8.00 |
| CHEMBL17350 | TRAXOPRODIL | 2.0 | 1 | 7.96 |
| CHEMBL159894 | — | — | 1 | 7.92 |
| CHEMBL161225 | — | — | 1 | 7.72 |
| CHEMBL158510 | — | — | 1 | 7.51 |
| CHEMBL161772 | — | — | 1 | 7.50 |
| CHEMBL161332 | — | — | 1 | 7.28 |
| CHEMBL162415 | — | — | 1 | 7.26 |
| CHEMBL161008 | — | — | 1 | 7.11 |
| CHEMBL353131 | — | — | 1 | 7.03 |
| CHEMBL347424 | — | — | 1 | 7.01 |
| CHEMBL161388 | — | — | 1 | 6.92 |
| CHEMBL345169 | — | — | 1 | 6.28 |
| CHEMBL159541 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423244 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL159675 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL158737 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL159762 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL159761 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL159416 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL159902 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL159453 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL159790 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL160027 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL161859 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL159425 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL350614 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL348727 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL159306 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL158874 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL305195 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL17350 | TRAXOPRODIL | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL159894 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL161225 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL158510 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL161772 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL161332 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL162415 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL161008 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL353131 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL347424 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL161388 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL345169 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL159541 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL350615 | — | Ki | = | 10000.0 | nM | 5.00 |