Compound Detail
CHEMBL350615
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Basic Information
| ChEMBL ID | CHEMBL350615 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QZARWWZWTPDHPY-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
210.3
MW (Da)
2.80
ALogP
1
HBA
2
HBD
35.9
PSA (Ų)
0.59
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 5.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 2B CHEMBL1904 | Ki | 5.0 | 5.0 | 10000.0 | 1 |
| Glutamate NMDA receptor; GRIN1/GRIN2B CHEMBL1907603 | Ki | 5.0 | 5.0 | 10000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate NMDA receptor; GRIN1/GRIN2B | Ki | = | 10000.0 | nM | 5.0 | Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors ... | 12639560 |
| Glutamate receptor ionotropic, NMDA 2B | Ki | = | 10000.0 | nM | 5.0 | Displacement of [3H]ifenprodil from GluN2B receptor (unknown origin) | 24412068 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12639560 | 10.1016/s0960-894x(02)01060-0 | Glutamate NMDA receptor; GRIN1/GRIN2B | 1 |
| 12639561 | 10.1016/s0960-894x(02)01061-2 | Glutamate receptor ionotropic, NMDA 2B | 1 |
| 24412068 | 10.1016/j.bmcl.2013.12.087 | Glutamate receptor ionotropic, NMDA 2B | 1 |
Data from ChEMBL 36 via Core Engine