Assay Detail
Binding
CHEMBL747371
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Evaluation of in vitro inhibitory activity against Neutral endopeptidase
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.30 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL358592 | — | — | 1 | 8.92 |
| CHEMBL356123 | — | — | 1 | 8.82 |
| CHEMBL320610 | — | — | 1 | 8.82 |
| CHEMBL149364 | — | — | 1 | 8.74 |
| CHEMBL146652 | — | — | 1 | 8.70 |
| CHEMBL424497 | — | — | 1 | 8.68 |
| CHEMBL343691 | — | — | 1 | 8.66 |
| CHEMBL148911 | — | — | 1 | 8.59 |
| CHEMBL147702 | — | — | 1 | 8.52 |
| CHEMBL356343 | — | — | 1 | 8.52 |
| CHEMBL356084 | — | — | 1 | 8.51 |
| CHEMBL144549 | — | — | 1 | 8.30 |
| CHEMBL435421 | — | — | 1 | 8.28 |
| CHEMBL10247 | THIORPHAN | -1.0 | 1 | 8.27 |
| CHEMBL147899 | — | — | 1 | 8.19 |
| CHEMBL342321 | — | — | 1 | 8.06 |
| CHEMBL144543 | — | — | 1 | 8.04 |
| CHEMBL148368 | — | — | 1 | 7.82 |
| CHEMBL342993 | — | — | 1 | 7.82 |
| CHEMBL64081 | — | — | 1 | 7.80 |
| CHEMBL147595 | — | — | 1 | 7.60 |
| CHEMBL479579 | PHOSPHORAMIDON | — | 1 | 7.58 |
| CHEMBL358338 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL358592 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL356123 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL320610 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL149364 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL146652 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL424497 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL343691 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL148911 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL147702 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL356343 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL356084 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL144549 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL435421 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL10247 | THIORPHAN | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL147899 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL342321 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL144543 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL148368 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL342993 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL64081 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL147595 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL479579 | PHOSPHORAMIDON | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL358338 | — | IC50 | = | 28.0 | nM | 7.55 |