Assay Detail
Binding
CHEMBL747373
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In vitro inhibition of Neutral endopeptidase (NEP) enzyme
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N-Phosphonomethyl dipeptides and their phosphonate prodrugs, a new generation of neutral endopeptidase (NEP, EC 3.4.24.11) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.46 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285038 | — | — | 1 | 8.72 |
| CHEMBL341868 | — | — | 1 | 8.70 |
| CHEMBL146594 | — | — | 1 | 8.52 |
| CHEMBL148521 | — | — | 1 | 8.40 |
| CHEMBL10247 | THIORPHAN | -1.0 | 1 | 8.32 |
| CHEMBL357903 | — | — | 1 | 8.30 |
| CHEMBL149646 | — | — | 1 | 8.00 |
| CHEMBL145937 | — | — | 1 | 7.96 |
| CHEMBL146631 | — | — | 1 | 7.85 |
| CHEMBL479579 | PHOSPHORAMIDON | — | 1 | 7.57 |
| CHEMBL342768 | — | — | 1 | 6.92 |
| CHEMBL149131 | — | — | 1 | 6.68 |
| CHEMBL358631 | — | — | 1 | 6.62 |
| CHEMBL145916 | — | — | 1 | 6.52 |
| CHEMBL148564 | — | — | 1 | 6.00 |
| CHEMBL147400 | — | — | 1 | 5.94 |
| CHEMBL2112023 | — | — | 1 | 5.75 |
| CHEMBL357607 | — | — | 1 | - |
| CHEMBL423937 | — | — | 1 | - |
| CHEMBL359254 | — | — | 1 | - |
| CHEMBL150209 | — | — | 1 | - |
| CHEMBL177646 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285038 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL341868 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL146594 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL148521 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL10247 | THIORPHAN | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL357903 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL149646 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL145937 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL146631 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL479579 | PHOSPHORAMIDON | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL342768 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL149131 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL358631 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL145916 | — | IC50 | = | 301.0 | nM | 6.52 |
| CHEMBL148564 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL147400 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL2112023 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL357607 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL423937 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL359254 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL150209 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL177646 | — | IC50 | > | 1000.0 | nM | - |