Assay Detail
Binding
CHEMBL747399
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Substituent variation in azabicyclic triazole- and tetrazole-based muscarinic receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.28 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL309432 | — | — | 1 | 8.55 |
| CHEMBL9967 | PIRENZEPINE | 2.0 | 1 | 6.67 |
| CHEMBL311703 | — | — | 1 | 5.72 |
| CHEMBL311799 | — | — | 1 | 5.72 |
| CHEMBL311562 | — | — | 1 | 5.68 |
| CHEMBL80723 | — | — | 1 | 5.57 |
| CHEMBL79040 | — | — | 1 | 5.55 |
| CHEMBL23118 | — | — | 1 | 5.55 |
| CHEMBL81281 | — | — | 1 | 5.54 |
| CHEMBL311036 | — | — | 1 | 5.51 |
| CHEMBL311989 | — | — | 1 | 5.44 |
| CHEMBL309638 | — | — | 1 | 5.44 |
| CHEMBL309729 | — | — | 1 | 5.41 |
| CHEMBL81492 | — | — | 1 | 5.37 |
| CHEMBL311297 | — | — | 1 | 5.36 |
| CHEMBL78697 | — | — | 1 | 5.36 |
| CHEMBL23335 | — | — | 1 | 5.35 |
| CHEMBL23721 | — | — | 1 | 5.34 |
| CHEMBL276975 | — | — | 1 | 5.29 |
| CHEMBL80917 | — | — | 1 | 5.28 |
| CHEMBL309281 | — | — | 1 | 5.24 |
| CHEMBL442975 | — | — | 1 | 5.14 |
| CHEMBL79020 | — | — | 1 | 4.87 |
| CHEMBL81314 | — | — | 1 | 4.84 |
| CHEMBL79374 | — | — | 1 | 4.84 |
| CHEMBL280219 | — | — | 1 | 4.83 |
| CHEMBL23563 | — | — | 1 | 4.80 |
| CHEMBL667 | ACETYLCHOLINE | 4.0 | 1 | 4.62 |
| CHEMBL82188 | — | — | 1 | 4.58 |
| CHEMBL79265 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL309432 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL9967 | PIRENZEPINE | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL311703 | — | IC50 | = | 1925.0 | nM | 5.72 |
| CHEMBL311799 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL311562 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL80723 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL79040 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL23118 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL81281 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL311036 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL311989 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL309638 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL309729 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL81492 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL78697 | — | IC50 | = | 4360.0 | nM | 5.36 |
| CHEMBL311297 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL23335 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL23721 | — | IC50 | = | 4523.0 | nM | 5.34 |
| CHEMBL276975 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL80917 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL309281 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL442975 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL79020 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL81314 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL79374 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL280219 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL23563 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL667 | ACETYLCHOLINE | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL82188 | — | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL79265 | — | IC50 | = | 30600.0 | nM | 4.51 |
| CHEMBL78820 | — | IC50 | = | 35600.0 | nM | 4.45 |
| CHEMBL309498 | — | IC50 | = | 38200.0 | nM | 4.42 |
| CHEMBL311008 | — | IC50 | = | 39900.0 | nM | 4.40 |
| CHEMBL311246 | — | IC50 | = | 46700.0 | nM | 4.33 |